Blood Brain Barrier-Targeted Therapeutics
Blood-brain barrier(BBB) is one of the major challenges in treating neurological disorders. New strategies such as carrier-mediated nanoparticles, liposomes, exosomes, and receptor-mediated transport systems, including peptide and antibody-based targeting, are being developed to overcome the challenges of the blood–brain barrier and enhance drug access to the central nervous system (CNS) effectively. Non-invasive approaches such as intranasal drug delivery are emerging as promising alternatives to bypass the blood–brain barrier. These strategies hold significant potential in the treatment of neurodegenerative diseases, including Alzheimer’s and Parkinson’s, as well as brain tumors, epilepsy, and central nervous system (CNS) infections. BBB-targeted drug delivery advances are essential for precision neuro-medicine, as they enable more effective treatment of central nervous system (CNS) disorders and hold the potential to significantly improve patient outcomes.